7 Predicting Kernicterus in Severe Unconjugated Hyperbilirubinemia
نویسندگان
چکیده
منابع مشابه
Pharmacological therapies for unconjugated hyperbilirubinemia.
Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion. Phototherapy, however, has several known disadvantages while exchange transfusion is associated with a significant morbidity, and even mortality. These harmful effects indicate the n...
متن کاملEffect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus.
Sodium phenobarbital and various hormones, compounds capable of hepatic enzyme induction, were given to an infant boy with congenital, nonhemolytic, unconjugated, hyperbilirubinemia and severe kernicterus for prolonged periods between the ages of 2 and 25 months to determine their effect on serum bilirubin concentrations. Phenobarbital, 5 mg/day orally, on two occasions decreased serum bilirubi...
متن کاملSevere neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium?
Despite efforts to eliminate permanent and irreversible brain damage due to bilirubin encephalopathy and kernicterus, these conditions continue to accompany us into the third millennium. This phenomenon occurs not only in developing countries with emerging medical systems, but in Westernized countries as well. Comprehensive guidelines to detect newborns with jaundice and treat those in whom hyp...
متن کاملUrinary excretion of biopyrrin in unconjugated hyperbilirubinemia
Biopyrrin is an oxidative metabolite of bilirubin. Biopyrrin is a tripyrrol moiety of bilirubin, including two regioisomers (biotripyrrin-a, 1,14,15,17tetrahydro-2,7,13-trimethyl-1,14-deoxy-3-vinyl-16Htripyrrin-8,12-dipropionic acid and biotripyrrin-b, 1,14,15,17-tetrahydro-3,7,13-trimethyl-1,14-deoxy2-vinyl-16H-tripyrrin-8,12-dipropionic acid: Fig. 1). For many years, bilirubin was regarded as...
متن کاملSevere Neonatal Hyperbilirubinemia and Kernicterus: Are These Still Problems in the Third Millennium?
Despite efforts to eliminate permanent and irreversible brain damage due to bilirubin encephalopathy and kernicterus, these conditions continue to accompany us into the third millennium. This phenomenon occurs not only in developing countries with emerging medical systems, but in Westernized countries as well. Comprehensive guidelines to detect newborns with jaundice and treat those in whom hyp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Paediatrics & Child Health
سال: 2004
ISSN: 1205-7088,1918-1485
DOI: 10.1093/pch/9.suppl_a.17a